Therapeutic calcium phosphate nanoparticle incorporating siRNA useful in treating disease

US10226424B2 · kind B2 · utility

Inventors

• Mylisa Parette · Bellefonte, US
• Danielle Asquino · Clearfield, US
• Kari Eyer · Sinking Spring, US
• James H. Adair · State College, US
• Jeff Davidson · Boalsburg, US
• Mark Kester · Harrisburg, US

Key dates

• Filing date: Aug 10, 2013
• Grant date: Mar 12, 2019
• Expiry date: Apr 16, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2982
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Stable, non-toxic, calcium phosphate nanoparticles are formed that incorporate one or more oligonucleotides. RNAi nucleotides may be incorporated and, in particular, siRNA nucleotides. Since the siRNA nanoparticles dissociate leaving only naturally occurring residual materials, calcium and phosphate, along with the siRNA, they are particularly useful as carrier vehicles. The ability to incorporate more than one siRNA provides a means to block or knock down the translation of multiple targeted proteins at the same time.