Composition for use in increasing engraftment efficacy of haematopoetic stem cells after transplantation
US10226465B2 · kind B2 · utility
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Key dates
| Filing date | Jan 27, 2016 |
| Grant date | Mar 12, 2019 |
| Priority date | — |
| Expiry date | Jan 27, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/734
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides the new use of composition comprising at least one inhibitor of dipeptidyl peptidase IV (DPP-IV) for increasing migration and homing of haematopoetic progenitor cells in stem cell transplanted recipients, wherein said haematopoetic stem and/or progenitor cells had been treated in vitro with an engraftment enhancing compound, specifically with a prostacyclin analog and a cAMP enhancer before transplantation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.