Bis(sulfonamide) derivatives and their use as mPGES inhibitors

US10227296B2 · kind B2 · utility

Assignee

• Arcturum Real Estate AB · SE

Inventors

• Peter Soderman · Grafton, GB
• Mats A. Svensson · New York, US
• Annika Kers · Malung, SE
• Liselott Öhberg · Söderhamn, SE
• Katharina Högdin · Knivsta, SE
• Andreas Hettman · Trosa, SE
• Jesper Hallberg · Stockholm, SE
• Maria Ek · Malung, SE
• Johan Bylund · Therwil, CH
• Johan Nord · Hagfors, SE

Key dates

• Filing date: Nov 24, 2015
• Grant date: Mar 12, 2019
• Expiry date: Nov 24, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to bis(sulfonamide) compounds and pharmaceutically acceptable salts thereof. The present invention also relates to pharmaceutical compositions comprising these compounds and to their use as a medicament for the treatment and/or prevention of a disease, disorder or condition in which modulation of microsomal prostaglandin E synthase-1 activity is beneficial, such as pain, inflammation and cancer.