Patent · US Active

Conversion of oxycodone base to oxycodone hydrochloride

US10227354B2 · kind B2 · utility

1Cited by

29References

24Claims

0Family size

Assignee

Cody Laboratories, Inc. · US

Inventors

Zinovy Itov · Cody, US
Vladimir F. Kuznetsov · Cody, US
Iouri Voitsekhovski · Cody, US

Key dates

Filing date	Dec 18, 2013
Grant date	Mar 12, 2019
Priority date	—
Expiry date	Dec 18, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D498/08
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.