Compounds and methods for kinase modulation, and indications therefor

US10227357B2 · kind B2 · utility

Assignee

• Plexxikon Inc. · US

Inventors

• Jack Lin · Hercules, US
• John Buell · San Francisco, US
• Katrina Chan · Fremont, US
• Todd Ewing · San Diego, US
• Prabha N. Ibrahim · Mountain View, US
• Marika Nespi · Berkeley, US
• Phuongly Pham · Hayward, US
• Songyuan Shi · Fremont, US
• Wayne Spevak · Berkeley, US
• Guoxian Wu · Palo Alto, US
• Jiazhong Zhang · Foster City, US
• Ying Zhang · Beijing, CN

Key dates

• Filing date: Sep 5, 2013
• Grant date: Mar 12, 2019
• Expiry date: Apr 23, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and mutant c-kit protein kinases.