Targeted delivery of proteins across the blood-brain barrier
US10227387B2 · kind B2 · utility
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7Claims
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Assignee
Inventor
Key dates
| Filing date | May 18, 2012 |
| Grant date | Mar 12, 2019 |
| Priority date | — |
| Expiry date | Aug 13, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/15043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Embodiments of the invention are directed to compositions comprising a peptide sequence, or a nucleic acid encoding the same, wherein the peptide sequence includes a receptor-binding region of apolipoprotein E (apoE), or a sequence variant or fragment thereof, for directing delivery of a given protein or therapeutic across the blood brain barrier. Embodiments of the invention are also directed to methods of using the compositions for treating or preventing a neurological disorder, disease, or symptom in a subject in need thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.