Capture reactions

US10227635B2 · kind B2 · utility

Assignee

• Molecular Loop Biosolutions, LLC · US

Inventors

• Mark Umbarger · Brookline, US
• Gregory Porreca · Cambridge, US
• Charles Towne · Shrewsbury, US
• George M. Church · Brookline, US

Key dates

• Filing date: Apr 17, 2012
• Grant date: Mar 12, 2019
• Expiry date: Apr 17, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/6869
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention generally relates to methods of performing a capture reaction. In certain embodiments, the method involves obtaining a nucleic acid, fragmenting the nucleic acid, and capturing a target sequence on the nucleic acid fragment using a capture moiety, such as a molecular inversion probe.