Multiplexed microfluidic cell sorting using laser induced cavitation bubbles
US10228317B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 21, 2017 |
| Grant date | Mar 12, 2019 |
| Priority date | — |
| Expiry date | Jul 21, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2015/1006
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Systems and methods for sorting particles are described. In one implementation, a system for sorting particles include a microfluidic device, a detection system, and an optical switching system. The microfluidic device includes a sample channel for passing through the particles in a fluid medium, a plurality of output channels fluidly connected to the sample channel at a plurality of junctions, and an actuation channel. The detection system detects a particle passing through the sample channel. The optical switching system deflects the particle to a target output channel based on results detected by the detection system. The optical switching system includes a modulation device configured to direct a laser pulse to an actuation region in the actuation channel corresponding to the target output channel. Advantageously, the systems and methods allow for accurate and dynamic sorting of a mixture of cells into a plurality of subpopulations using a simple microfluidic device.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.