Device and methods for analysis of biomolecule structure, dynamics and activity
US10228337B2 · kind B2 · utility
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2References
16Claims
0Family size
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Key dates
| Filing date | Dec 5, 2013 |
| Grant date | Mar 12, 2019 |
| Priority date | — |
| Expiry date | Jun 11, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B15/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides a method for determining the 3-dimensional or 3-D atomic resolution structure of a biomolecule using chemical shift data obtained from the biomolecule having one or more selectively isotopically labeled biomolecule monomers and interrogation of same using an NMR device. Methods also comprise use of a low-field NMR device and structure determination method to determine the 2-D and 3-D structure of the biomolecule, for example, a polynucleotide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.