Apparatus and method for the assessment of concentration profiling and permeability rates
US10228358B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 14, 2016 |
| Grant date | Mar 12, 2019 |
| Priority date | — |
| Expiry date | Apr 14, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2015/086
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An apparatus for the combined assessment of dissolution and permeability relies on a receiver chamber that is contained within a donor chamber. A membrane is provided between the two chambers. Measurements can be taken to determine solute amounts of a drug introduced in the donor chamber and amounts of permeated solute in the receiver chamber. Also described are techniques for the assessment of a dissolution rate and total amount of dissolved compound, together with their effect on absorption potential of a compound or a compound product as well as approaches for evaluating in vivo relevant differences between formulations of a compound through their effect on the absorption potential of the compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.