Additive channels

US10228381B2 · kind B2 · utility

Assignee

• EMULATE, INC. · US

Inventors

• Daniel Levner · Brookline, US
• Christopher David Hinojosa · Cambridge, US
• Norman Wen · Dedham, US
• Jacob Fraser · Somerville, US
• Justin Nguyen · Medford, US
• Riccardo Barrile · Boston, US
• Geraldine Hamilton · Cambridge, US
• Catherine Karalis · Brookline, US
• Hyoungshin Park · Newton, US
• Antonio Varone · Riverdale, US
• Andries Van der Meer · Enschede, NL
• Monicah Otieno · Millstone Township, US
• David Conegliano · Boston, US

Key dates

• Filing date: Jul 12, 2017
• Grant date: Mar 12, 2019
• Expiry date: Jul 12, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/10
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.