Biocompatible polymeric system for targeted treatment of thrombotic and hemostatic disorders

US10231993B2 · kind B2 · utility

Assignee

• University of Washington through its Center for Commercialization · US

Inventors

• Suzie Hwang Pun · Seattle, US
• Leslie Wan-Gee Chan · Boston, US
• Nathan White · Menlo Park, US

Key dates

• Filing date: Jun 27, 2014
• Grant date: Mar 19, 2019
• Expiry date: Jun 27, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A biocompatible polymer to which a plurality of clot-modulating peptides (CMPs) are bound. The polymer comprises repeating units of hydrophilic monomers and display monomers to which the CMPs are bound. For example, the CMPs can be fibrin binding peptides (FBPs) that enhance clot formation by cross-linking that occurs within and between fibers by the plurality of fibrin-binding peptides during fibrin polymerization. The polymers of the invention can be used to modulate clotting in a variety of ways via multivalent display of fibrin-binding peptides and other clot-binding and clot-modulating moieties on polymer or co-polymer backbones. In addition to clot-modulating moieties, imaging agents and therapeutic agents can be conjugated to the polymers to facilitate imaging of blood flow and thrombosis, and for treatment of clotting-related disorders.