Immunomodulatory oncolytic adenoviral vectors, and methods of production and use thereof for treatment of cancer
US10232053B2 · kind B2 · utility
18Cited by
1References
5Claims
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Key dates
| Filing date | Dec 7, 2017 |
| Grant date | Mar 19, 2019 |
| Priority date | — |
| Expiry date | Dec 7, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/203
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are compositions and methods for treating cancer in a subject. This involves administering an oncolytic virus containing a heterologous DNA sequence encoding one or more immunomodulatory and/or immunostimulatory polypeptide(s) of interest to the subject under conditions effective to enhance an anti-tumor immune response in the subject, and to treat cancer. It also relates to a method of enhancing the delivery to and distribution within a tumor mass of therapeutic viruses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.