Gel-forming system for removing urinary calculi and fragments thereof

US10232079B2 · kind B2 · utility

Assignees

• Fraunhofer-Gesellschaft zur förderung der angewandten Forschung e.V. · DE
• Albert-Ludwigs-Universitaet Freiburg · DE

Inventors

• Ingo Grunwald · Bremen, DE
• Katharina Richter · Bremen, DE
• Arkadiusz Miernik · Freiburg (Elbe), DE
• Martin Schoenthaler · Glückstadt, DE

Key dates

• Filing date: Aug 22, 2013
• Grant date: Mar 19, 2019
• Expiry date: Aug 22, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/26
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Primarily described are gel-forming systems, consisting of or comprising a composition (A), comprising one or several cationically crosslinkable polymer(s), and a composition (B), comprising one or several crosslinking agent(s) for crosslinking the cationically crosslinkable polymer(s) for use in a method for removing urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, from a region of the urinary tract, more particularly a kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, with the following steps: (i) providing the compositions (A) and (B), (ii) introducing the compositions (A) and (B) into a region of the urinary tract, more particularly the kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, under conditions enabling crosslinking of the cationically crosslinkable polymer(s) upon contact of composition (A) with composition (B) so that a crosslinked gel is formed that partly or fully surrounds the urinary calculi and/or fragments thereof, more par…