Substituted nitrogen-containing heterocyclic derivatives, pharmaceutical compositions comprising the same and applications of antitumor thereof

US10233180B2 · kind B2 · utility

Assignees

• ZHEJIANG UNIVERSITY · CN
• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN

Inventors

• Xiaowu Dong · Zhejiang, CN
• Jia-He Li · Cockeysville, US
• Bo Yang · Zhejiang, CN
• Yongzhou Hu · Zhejiang, CN
• Yubo Zhou · Shanghai, CN
• Qinjie WENG · Hangzhou City, CN
• Wenhu Zhan · Elmhurst, US
• Lei Xu · Ottawa, CA
• Tao Liu · Shanghai, CN
• Qiaojun HE · Hangzhou City, CN

Key dates

• Filing date: Mar 21, 2015
• Grant date: Mar 19, 2019
• Expiry date: Mar 21, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are new substituted nitrogen-containing heterocyclic derivatives represented by formula (I) as AKT inhibitors, optical isomers, pharmaceutically acceptable salts or solvates thereof, wherein the definition of R1, R2, R3, R4, R5, R6, ring A, ring C, B, Q, Y, Z and m is shown in the description for details. In addition, medicaments comprising the derivatives as active components are also disclosed, which can be useful for treating proliferative diseases, such as cancer and inflammation, especially diseases relating to AKT kinase.