Substituted spirocyclic inhibitors of autotaxin

US10233182B2 · kind B2 · utility

Assignee

• X-Rx, Inc. · US

Inventors

• Lee Babiss · Waltham, US
• Matthew Clark · Waltham, US
• Anthony D. Keefe · Cambridge, US
• Mark J. Mulvihill · Melville, US
• Haihong Ni · Shanghai, CN
• Louis Renzetti · Waltham, US
• Frank Ruebsam · Beijing, CN
• Ce Wang · Beijing, CN
• Zhifeng Xie · Beijing, CN
• Ying Zhang · Beijing, CN

Key dates

• Filing date: Feb 14, 2018
• Grant date: Mar 19, 2019
• Expiry date: Feb 14, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F5/025
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.