Magnetic resonance imaging contrast agent capable of detecting hydrogen peroxide and reducing reactive oxygen species
US10233205B2 · kind B2 · utility
0Cited by
3References
20Claims
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Key dates
| Filing date | Aug 5, 2016 |
| Grant date | Mar 19, 2019 |
| Priority date | — |
| Expiry date | Jan 30, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/103
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The current invention provides metal ion complexes with an organic ligand, compositions comprising such complexes. In particular, these complexes are capable of reacting with a reactive oxygen species in a subject and increase their T1-weighted relaxivities so a clinical MRI scanner can detect an oxidative stress hotspot in the subject. The disclosed complexes also exhibit excellent anti-oxidant properties and low cell toxicity, therefore can be used as a therapeutic agent to relieve oxidative stress in the subject, or as both a MRI contrast agent and therapeutic agent in a composition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.