pH-dependent antibodies targeting the transferrin receptor and methods of use thereof to deliver a therapeutic agent
US10233252B2 · kind B2 · utility
12Cited by
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28Claims
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Key dates
| Filing date | Dec 15, 2016 |
| Grant date | Mar 19, 2019 |
| Priority date | — |
| Expiry date | Dec 15, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/01
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A pH-dependent antibody that binds an antigen with high affinity at a first pH and rapidly dissociates at a second pH, wherein the antigen is a transferrin receptor (TfR), wherein the association at the second pH/the first pH is less than 20%, and wherein the pH-dependent antibody comprises at least two consecutive histidine residues at a single complementarity determining region (CDR) is disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.