Patent · US Active

Differentiation of pluripotent stem cells

US10233421B2 · kind B2 · utility

0Cited by

79References

14Claims

0Family size

Assignee

JANSSEN BIOTECH, INC. · US

Inventors

Janet Davis · Skillman, US
Jiajian Liu · Shanghai, CN
Christine Parmenter · Skillman, US
Pascal Ghislain Andre Bonnet · Beerse, BE

Key dates

Filing date	Mar 13, 2017
Grant date	Mar 19, 2019
Priority date	—
Expiry date	Mar 13, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2533/90
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.