Ligation-based detection of genetic variants
US10233496B2 · kind B2 · utility
1Cited by
125References
11Claims
0Family size
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Key dates
| Filing date | Oct 9, 2015 |
| Grant date | Mar 19, 2019 |
| Priority date | — |
| Expiry date | Oct 9, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/16
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation—, e.g., the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary to a region between the fixed sequence oligonucleotides—combined with detection of levels of particular genomic regions using array hybridization.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.