Analysis of the molecular weight distribution of complex polypeptide mixtures
US10234461B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Sep 23, 2016 |
| Grant date | Mar 19, 2019 |
| Priority date | — |
| Expiry date | Feb 2, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6803
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to simple size exclusion chromatography (SEC) analytical methods useful for the assessment of accurate molecular weight distributions (MWDs) of certain polypeptide mixtures known as glatiramoids. The use of a SEC method based on one or more broad MWD standards furnishes the absolute (not relative) molecular weight distribution profile of complex polypeptide mixtures like, for instance, the glatiramer acetate (GA) polymer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.