Aiding assessment of prognosis in inflammatory disease by measuring octameric PTX3

US10234463B2 · kind B2 · utility

Assignee

• KING'S COLLEGE LONDON · GB

Inventors

• Manuel Mayr · Walldorf, DE
• Friederike Cuello · London, GB

Key dates

• Filing date: May 20, 2014
• Grant date: Mar 19, 2019
• Expiry date: May 20, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/7095
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Some embodiments are directed to a method of collecting information useful in predicting clinical outcome in a subject, the method including providing a sample from said subject, and determining the level of octameric PTX3 in said sample, wherein determining the level of octameric PTX3 includes measuring the total amount of PTX3 present, and measuring the amount of octameric PTX3 present, and calculating the proportion of total PTX3 which is present as octamer, wherein if the proportion of octameric PTX3 is greater than 50%, the subject is identified as a likely non-survivor. Some embodiments are also directed to a method of collecting information useful in predicting clinical outcome in a subject, the method including providing a sample from said subject, and determining the level of octameric PTX3 in said sample, wherein an elevated level of octameric PTX3 compared to a reference level indicates a reduced likelihood of survival.