Hyperbranched polyglycerol-coated particles and methods of making and using thereof
US10238581B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 11, 2015 |
| Grant date | Mar 26, 2019 |
| Priority date | — |
| Expiry date | May 13, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/624
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.