D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
US10238680B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 30, 2015 |
| Grant date | Mar 26, 2019 |
| Priority date | — |
| Expiry date | Nov 30, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are compounds, compositions, and methods for the treatment of viral infections, for example, Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are D-amino acid phosphoramidate halogeno pyrimidine nucleoside analog compounds which display remarkable efficacy and bioavailability for the treatment of, for example, HCV infection in a human. In certain embodiments, the compounds are of Formula I: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein: PD, X, R1, R2, RA, and RB are as described herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.