Carboxylic acid derivatives and use thereof in the preparation of prodrugs

US10239851B2 · kind B2 · utility

Assignee

• Qingeng Li · CN

Inventors

• Qingeng Li · Chongqing, CN
• Tao Wang · Farmington, US
• Gang Chen · Sammamish, US
• Yuanzhong Wang · Shanghai, CN
• Wei Mao · Chengdu, CN
• Tong Wu · Västerås, SE
• Lingguo Zeng · Chongqing, CN

Key dates

• Filing date: Feb 16, 2015
• Grant date: Mar 26, 2019
• Expiry date: Feb 16, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention discloses a class of carboxylic acid derivatives and use thereof in preparation of prodrugs. The carboxylic acid derivatives have the general formula (I), wherein R1 is H or alkyl; X is H or F; Y is F or fluoroalkyl; n is 0, 1, 2, 3, 4, 5, or 6; W is W1 or W2; W1 is NR2R3, NR2R3.A, R2 and R3 are each independently H, alkyl, cycloalkyl, or a protecting group for amino; m is 0, 1, 2, or 3; A is an acid; W2 is COOR4, OPO(OR4)2, or PO(OR)2; R4 is H, or a protecting group for carboxyl or hydroxyl in phosphoric acid.