Broad spectrum beta-lactamase inhibitors
US10239890B2 · kind B2 · utility
2Cited by
82References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 29, 2018 |
| Grant date | Mar 26, 2019 |
| Priority date | — |
| Expiry date | May 29, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/60
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making beta-lactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.