Composition and method for treating androgen-dependent disorders

US10240132B2 · kind B2 · utility

Assignee

• Technion Research & Development Foundation Limited · IL

Inventors

• Roee AMIT · Haifa, IL
• Alexey Tomsov · Carmiel, IL
• Orna Atar · Haifa, IL
• Liron Abrahami · Zichron Ya'akov, IL
• Yael Annis · Pardes Hana-Karkur, IL
• Roni Cohen · Zichron Ya'akov, IL
• Alexandra Ereskovsky · Nesher, IL
• Noa Katz · Haifa, IL
• Lior LEVY · Haifa, IL
• Maayan Lufton · Kiryat Yam, IL
• Tal Ofek · Haifa, IL
• Sagi Sheinkman · Netanya, IL
• Nitzan Shmuel · Nofit, IL
• Inbal Vaknin · Or Akiva, IL
• Ruth Veksler · Carmiel, IL
• Adi Yannai · Haifa, IL

Key dates

• Filing date: Mar 28, 2017
• Grant date: Mar 26, 2019
• Expiry date: Mar 28, 2037

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Chimeric polypeptides comprising a dihydrotestosterone (DHT) reductase moiety, such as 3 alpha-hydroxysteroid dehydrogenase (3α-HSD), fused to a signal peptide moiety, polynucleotides encoding same, and compositions comprising at least one microorganism cell capable of secreting the chimeric polypeptide, are provided. Further provided are methods and kits for treating, preventing or ameliorating androgen-dependent disorders, including but not limited to androgenic alopecia.