Avian influenza virus miRNA, and appraisal, detection, and application thereof
US10240150B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 9, 2014 |
| Grant date | Mar 26, 2019 |
| Priority date | — |
| Expiry date | Dec 9, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/11
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to an avian influenza virus miRNA and the identification, detection and application thereof. In particular, a kind of specific microRNA, miR-HA-3p, is screened for the first time through detecting the microRNA expression levels in samples of animals with avian influenza. The experiments prove that the miR-HA-3p, as a microRNA marker, can be very effective in detecting avian influenza virus and avian influenza. Furthermore, inhibiting the function of miR-HA-3p can be very effective in relieving symptoms of avian influenza and treating avian influenza. The microRNA revealed in the present invention for the first time can be developed into a detection agent and a therapeutic agent as well as the corresponding kits for the detection and treatment of avian influenza (e.g., H5N1).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.