Methods and apparatus for monitoring interactions between particles and molecules using nanophotonic trapping
US10241233B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 12, 2015 |
| Grant date | Mar 26, 2019 |
| Priority date | — |
| Expiry date | Aug 12, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG21K1/006
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for characterizing an interaction between a first particle and a second particle is provided. The method includes the steps of: (i) providing an optical trap system including a photonics-based trap, a light source, and a camera; (ii) optically trapping, using the photonics-based trap, the first particle; (iii) obtaining a first measurement of a trap stiffness of the photonics-based trap; (iv) introducing the second particle to the optically trapped particle; (v) incubating the first and second particles under conditions suitable for an interaction between the first and second particles; (vi) obtaining a second measurement of the trap stiffness of the photonics-based trap after the incubation; and (vii) determining, using the first measurement of trap stiffness and the second measurement of trap stiffness, a property of the interaction between the first particle and the second particle.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.