Pulmonary delivery of mRNA to non-lung target cells

US10245229B2 · kind B2 · utility

Assignees

• TRANSLATE BIO, INC. · US
• ethris GmbH · DE

Inventors

• Michael Heartlein · Boxborough, US
• Braydon Charles Guild · Concord, US
• Frank DeRosa · Lexington, US
• Carsten Rudolph · Krailling, DE
• Christian Plank · Wien, AT

Key dates

• Filing date: Jun 7, 2013
• Grant date: Apr 2, 2019
• Expiry date: Jun 7, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/6018
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions comprising mRNA formulated for pulmonary administration and related methods for delivery of the mRNA and/or encoded protein to a non-lung cell or tissue. The compositions and methods may be used to prevent or ameliorate the symptoms of diseases associated with the mRNA encoded protein.