Organic compounds

US10245260B2 · kind B2 · utility

Assignee

• INTRA-CELLULAR THERAPIES, INC. · US

Inventors

• Wei Yao · Shanghai, CN
• Peng Li · New York, US
• Robert E. Davis · San Diego, US
• Sharon Mates · New York, US
• Kimberly VANOVER · New York, US
• Gretchen SNYDER · New York, US

Key dates

• Filing date: Jul 26, 2017
• Grant date: Apr 2, 2019
• Expiry date: Oct 17, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving the 5-HT2A receptor, the serotonin transporter (SERT), pathways involving the dopamine D1 and D2 receptor signaling system, and/or the μ-opioid receptor.