Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors

US10246467B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Juergen Ramharter · Wien, AT
• Joachim BROEKER · Miedling, AT
• Annika Gille · Ulm, DE
• Andreas Gollner · Wien, AT
• Manuel HENRY · Schemmerhofen, DE
• Nina Kerres · Wien, AT
• Harald WEINSTABL · Wien, AT

Key dates

• Filing date: Aug 20, 2015
• Grant date: Apr 2, 2019
• Expiry date: Aug 20, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08K3/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention encompasses compounds of formula (I) wherein the groups R1 to R7, A, V, W, X, Y, n, r and q are defined in claim 1, their use as inhibitors of MDM2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases, and synthetic intermediates.