Potassium channel blockers and use thereof in the treatment of autoimmune diseases

US10246496B2 · kind B2 · utility

Assignees

• LA TROBE UNIVERSITY · AU
• MONASH UNIVERSITY · AU
• Baylor College of Medicine · US
• PEPTIDES INTERNATIONAL, INC. · US

Inventors

• Raymond S. Norton · Elmore, AU
• Shih-Chieh Chang · Taipei, TW
• Michael W. Pennington · Fontana, US
• Christine Beeton · Pearland, US
• Brian John Smith · Melbourne, AU

Key dates

• Filing date: Aug 14, 2015
• Grant date: Apr 2, 2019
• Expiry date: Aug 14, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/21
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel analogues of the sea anemone Stichodactyla helianthus toxin ShK, and their use as, for example, therapeutic agents for treating autoimmune diseases are disclosed. The analogues comprise a ShK toxin polypeptide and an N-terminal extension comprising an amino acid sequence according to formula (I): wherein X−4 is D, E or other negatively-charged amino acid or derivative thereof, X−3 is E, I, L, S, V, W or a tryptophan derivative, X−2 is any amino acid, X−1 is any amino acid, a is absent or a first additional moiety, and b is absent or a second additional moiety. a-X−4X−3X−2X−1-b(SEQ ID NO: 3)  (I)