Phosphoketolases for improved production of acetyl coenzyme A-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids
US10246694B2 · kind B2 · utility
1Cited by
7References
20Claims
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Key dates
| Filing date | Apr 10, 2014 |
| Grant date | Apr 2, 2019 |
| Priority date | — |
| Expiry date | Jul 31, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y401/02009
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This present invention relates to cultured recombinant cells comprising a heterologous phosphoketolase (PKL) polypeptide that are capable of increased production of acetyl coenzyme A-derived metabolites, as well as methods for producing and using the same. In some embodiments, the recombinant cells further comprise one or more mevalonate (MVA) pathway polypeptides for the production of isoprenoid precursors, isoprene and isoprenoids.
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