Photosynthetic production of 3-hydroxybutyrate from carbon dioxide
US10246726B2 · kind B2 · utility
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Key dates
| Filing date | Mar 28, 2018 |
| Grant date | Apr 2, 2019 |
| Priority date | — |
| Expiry date | Mar 28, 2038 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/59
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Construction and expression of synthetic pathways to produce (S) or (R)-3-hydroxybutyrate (3HB) as enantiomerically-pure products by genetically engineering cyanobacterium Synechocystis sp. PCC 6803. Under optimized growth conditions, the pathway employing phaA and phaB from R. eutropha was the most effective, producing up to 533.4±5.5 mg/l (R)-3HB after 21 days photosynthetic cultivation. For the first time, the feasibility and high efficiency of producing 3HB using solar energy and CO2 as sole energy and carbon sources by engineered cyanobacteria is demonstrated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.