Polymorphic and amorphous forms of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide

US10251847B2 · kind B2 · utility

Assignee

• BIOELECTRON TECHNOLOGY CORPORATION · US

Inventors

• Paul Mollard · Domène, FR
• Christopher R. Cornell · Mountain View, US
• Kieron E. Wesson · Menlo Park, US
• Peter Giannousis · Mountain View, US
• Shazad Suchit · Devens, US
• Mahmoud Mirmehrabi · Halifax, CA

Key dates

• Filing date: Dec 16, 2015
• Grant date: Apr 9, 2019
• Expiry date: Dec 16, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide and methods of using such compositions for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. Further disclosed are methods of making such polymorphic and amorphous forms.