Compounds for bone healing

US10251860B2 · kind B2 · utility

Assignees

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Michael W. Epperly · Pittsburgh, US
• Joel S. Greenberger · Dorpsstraat, US
• Peter Wipf · Pittsburgh, US
• Julianne Glowacki · Brookline, US

Key dates

• Filing date: Feb 27, 2018
• Grant date: Apr 9, 2019
• Expiry date: Feb 27, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D305/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are embodiments of a method of accelerating bone healing in a subject in need thereof, comprising administering to the subject a compound disclosed here. The method may further comprise selecting or identifying a subject that has bone damage, or is a risk of developing bone damage. The compound may be administered after bone damage has occurred, or it may be administered prophylactically. The compound may be administered to a subject that has not and/or will not be exposed to radiation. In other embodiments, the subject has been and/or will be exposed to radiation.