Transition metal-catalyzed protocarboxylation of α-halo-acrylic acid derivatives

US10252994B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Mai Thi Quynh DANG · Ingelheim am Rhein, DE
• Thomas Armin Hampel · Frankfurt, DE
• Sandra Koch · Bad Kreuznach, DE
• Fredrik Lars Nordstrom · Ridgefield, US
• Jonathan Timothy Reeves · Ridgefield, US
• Carsten Reichel · Rheinböllen, DE
• Marvin Schoerer · Oberhausen, DE
• Christian Stange · Ingelheim am Rhein, DE
• Ivan N. Volchkov · Sandy Hook, US
• Li Zhong · New Milford, US
• Uwe Johannes Zimmermann · Trebur, DE

Key dates

• Filing date: Feb 22, 2018
• Grant date: Apr 9, 2019
• Expiry date: Feb 22, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C231/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a method for the synthesis of a halo olefin of formula (I) wherein Hal, R1, R2, R3, R4, X and Y are as defined herein, or a salt thereof.