Process for the preparation of (r)-8-(3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1h-purine-2,6-dione

US10253026B2 · kind B2 · utility

Assignee

• Boenringer Ingelheim International GmbH · DE

Inventors

• Weitong Dong · Shanghai, CN
• Yao Huang · Shanghai, CN
• Shengmin Su · Shanghai, CN
• Yongfen Sun · Shanghai, CN
• Pengtao Zhang · Shanghai, CN

Key dates

• Filing date: Jun 24, 2016
• Grant date: Apr 9, 2019
• Expiry date: Jun 24, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to a method for preparation of a xanthine-based compound of formula (I): as well as to intermediates useful in such preparation.