7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds and their use as mutant IDH1 inhibitors

US10253041B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Renato Alejandro Bauer · Indianapolis, US
• Serge Louis Boulet · Fishers, US
• Timothy Paul Burkholder · Carmel, US
• Santiago CARBALLARES MARTIN · Madrid, ES
• James Gillig · Indianapolis, US
• Raymond Gilmour · Indianapolis, US
• Wenceslao Lumeras · Madrid, ES
• Zhipei Wu · Fishers, US

Key dates

• Filing date: Jul 21, 2016
• Grant date: Apr 9, 2019
• Expiry date: Jul 21, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds of Formula I, formulations containing those compounds, and their use as mutant isocitrate dehydrogenase 1 enzyme inhibitors.