Patent · US Active

Conjugates of proteins and multivalent cell-penetrating peptides and their uses

US10253099B2 · kind B2 · utility

1Cited by

0References

20Claims

0Family size

Assignee

RUPRECHT - KARLS - UNIVERSITÄT HEIDELBERG · DE

Inventors

Matthias Strieker · Los Alamos, US
Walter Mier · Bensheim, DE
Uwe Haberkorn · Schwetzingen, DE

Key dates

Filing date	Dec 4, 2013
Grant date	Apr 9, 2019
Priority date	—
Expiry date	Sep 29, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/24
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to conjugates comprising a protein and multivalent cell-penetrating peptide(s), each multivalent cell-penetrating peptide comprising at least two cell-penetrating peptides, wherein the multivalent cell-penetrating peptide(s) is/are covalently attached to the protein. The present invention furthermore relates to a method of generating the conjugates and to their medical uses, in particular their use in the diagnosis, prevention and/or treatment of diseases. The present invention relates to methods of diagnosis, prevention and/or treatment of diseases, comprising administering the conjugates of the invention to a patient.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.