Patent · US Active

Visualizing modified nucleotides and nucleic acid interactions in single cells

US10253356B2 · kind B2 · utility

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0References

14Claims

0Family size

Assignee

Sigma-Aldrich Co. LLC · US

Inventors

Vikas B. Palhan · New York, US
Carol Kreader · Kirkwood, US

Key dates

Filing date	Dec 22, 2015
Grant date	Apr 9, 2019
Priority date	—
Expiry date	Feb 3, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2565/601
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Methods for visualizing modified nucleotides in a specific nucleic acid sequence or specific nucleic acid sequence interactions in single cells, wherein the methods comprise coupling an in situ hybridization (ISH) reaction with a proximity ligation assay (PLA) reaction.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.