Method and kit for assessment of sodium channel-related anti- or pro-arrhythmic potential of compounds

US10254273B2 · kind B2 · utility

Assignee

• RUPRECHT - KARLS - UNIVERSITÄT HEIDELBERG · DE

Inventors

• Michael Koenen · Heidelberg, DE
• Pessah Yampolsky · Wien, AT
• Patrick Schweizer · Quedlinburg, DE
• Dierk Thomas · Heidelberg, DE
• Hugo Katus · Heidelberg, DE

Key dates

• Filing date: Aug 11, 2015
• Grant date: Apr 9, 2019
• Expiry date: Aug 11, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/6872
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to an in vitro method for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s). The present invention also relates to compound(s) identified or evaluated in the method of the invention for use in the treatment of a heart disease. The present invention further relates to the use of the density change of cardiac Nav 1.5 sodium channels in intercalated discs of cardiomyocytes as marker and/or diagnostic for the anti- or pro-arrhythmic potential of a compound, the cardiotoxicity of a compound or modulation capacity of cardiomyocyte function by said compound, and/or in preclinical assessment for cardiac liability of compounds and cardio-safety assessment. The present invention further relates to a kit for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s).