Micronized insulin and micronized insulin analogues prepared under acidic conditions, and methods of manufacturing the same under acidic conditions
US10258573B2 · kind B2 · utility
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18References
20Claims
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Key dates
| Filing date | Jul 8, 2015 |
| Grant date | Apr 16, 2019 |
| Priority date | — |
| Expiry date | Jul 8, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of preparing an inhalable insulin suitable for pulmonary delivery includes: dissolving an insulin raw material in an acidic solution to form a dissolved insulin solution; titrating the dissolved insulin solution with a buffer solution to form a suspension comprising micronized insulin particles; and stabilizing the micronized insulin particles.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.