Method of preparing itraconazole preparation
US10258574B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Sep 8, 2015 |
| Grant date | Apr 16, 2019 |
| Priority date | — |
| Expiry date | Jan 5, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P33/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for preparing an itraconazole formulation including: dissolving a mixture of itraconazole and L-ascorbic acid with a mixed solvent of dichloromethane and methanol, adding a hydroxypropyl methylcellulose and a pluronic F-127 and then dichloromethane into the mixed solvent to obtain a raw material solution; feeding a carbon dioxide into a crystallization autoclave in a supercritical fluid crystallization equipment system through a pressure regulating valve; spraying the solution into the crystallization autoclave via a spray nozzle, separating out composite particles from the solution and collecting the composite particles at a bottom of the crystallization autoclave, and encapsulating the composite particles to obtain a itraconazole formulation with decreased particle size and increased bioavailability.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.