Protective effect of DMPC, DMPG, DMPC/DMPG, EGPG, LysoPG and LysoPC against drugs that cause channelopathies

US10258691B2 · kind B2 · utility

Assignee

• Signpath Pharma Inc. · US

Inventors

• Lawrence Helson · Quakertown, US
• George M. Shopp · Boulder, US
• Annie Bouchard · Stoke, CA
• Muhammed Majeed · Plainsboro, US
• Stephen W. Burgess · Chelsea, US
• Walter A. Shaw · Rehovot, IL

Key dates

• Filing date: Jun 3, 2015
• Grant date: Apr 16, 2019
• Expiry date: Jun 3, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention includes compositions and methods for preventing one or more cardiac channelopathies or conditions resulting from irregularities or alterations in cardiac patterns caused by an active agent or a drug in a human or animal subject comprising: an amount of a lysophosphatidyl compound adapted for oral administration effective to reduce or prevent one or more cardiac channelopathies or conditions resulting from irregularities or alterations in cardiac patterns caused by the active agent or drug. Such compositions may further comprise a monoglyceride, a free fatty acid or a combination of the foregoing, including, e.g., a eutectic mixture.