Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions

US10258698B2 · kind B2 · utility

Assignee

• ModernaTX, Inc. · US

Inventors

• Stephen Hoge · Brookline, US
• Orn Almarsson · Shrewsbury, US
• David D. Hile · Westborough, US
• Ciaran Lawlor · Cambridge, US
• John Podobinski · Boston, US
• Staci Sabnis · Somerville, US
• Antonin de Fougerolles · Waterloo, BE
• Divakar Ramakrishnan · Lexington, US
• Kristy M. Wood · Wellesley, US

Key dates

• Filing date: Mar 14, 2014
• Grant date: Apr 16, 2019
• Expiry date: Mar 14, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/88
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.