Methods for preparing fused bicyclic 2, 4-diaminopyrimidine derivatives

US10259794B2 · kind B2 · utility

Assignee

• Cephalon LLC · US

Inventors

• Shawn P. Allwein · Downingtown, US
• Roger P. Bakale · Summit, US
• Dale R. Mowrey · Glenmoore, US
• Daniel Petrillo · Perth, AU
• Sander Kluwer · Amsterdam, NL

Key dates

• Filing date: Dec 23, 2015
• Grant date: Apr 16, 2019
• Expiry date: Dec 23, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure is directed to improved methods useful for the preparation of, for example, 2-[[5-chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5Hbenzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]-N-methyl-benzamide (CEP-37440).