Beta-hairpin peptidomimetics

US10259847B2 · kind B2 · utility

Assignee

• POLYPHOR AG · CH

Inventors

• Daniel Obrecht · Amriswil, CH
• Anatol Luther · Binzen, DE
• Francesca Bernardini · Hésingue, FR
• Gildas Deniau · Zürich, CH
• Alexander Lederer · Basel, CH

Key dates

• Filing date: Sep 29, 2015
• Grant date: Apr 16, 2019
• Expiry date: Sep 29, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Beta-hairpin peptidomimetics of the general formula (I), cyclo[P1-P2-P3-P4-P5-P6-P7-P8-P9-P10-P11-P12-T1-T2], and pharmaceutically acceptable salts thereof, with P1 to P12, T1 and T2 being elements as defined in the description and the claims, have Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.