Modified DKK2 protein, nucleic acid encoding the same, preparation method thereof, and use thereof
US10259850B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Feb 3, 2016 |
| Grant date | Apr 16, 2019 |
| Priority date | — |
| Expiry date | Feb 3, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are a modified DKK2 polypeptide according to an aspect, a nucleic acid encoding the same, a preparation method thereof, and use thereof. Accordingly, a modified DKK2 protein having an additional glycosyl group or improved binding affinity for a substrate LRP6 may be efficiently prepared, thereby being used for promoting angiogenesis or preventing or treating vascular permeability-related diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.